DMTF1 Antibody

CAT: 0223-59-362Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-59-362Size:400 µL
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Background
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
9988
Swiss Prot
Q9Y222
Accession Number
Q9Y222
Host
Rabbit
Reactivity
Human
Immunogen
This DMTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-616 amino acids from the C-terminal region of human DMTF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
84 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DMTF1
NCBI Official Name
Cyclin-D-binding Myb-like transcription factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Liu, Y., et al. Mol. Psychiatry (2010) In press :
Background Reference 02
Sugiyama, T., et al. Expert Rev. Mol. Diagn. 8 (4) :435-447 (2008)
Background Reference 03
Inoue, K., et al. Cancer Res. 68 (12) :4487-4490 (2008)
Background Reference 04
Tschan, M.P., et al. Leukemia 22 (5) :1087-1090 (2008)
Other Product Names
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Tested Applications
WB
Protein ID
74762040
Physical Properties
Liquid

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