DMTF1 Antibody

• Background:

  This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  9988

• Swiss Prot:

  Q9Y222

• Accession Number:

  Q9Y222

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DMTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-616 amino acids from the C-terminal region of human DMTF1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  84 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DMTF1

• NCBI Official Name:

  Cyclin-D-binding Myb-like transcription factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, Y., et al. Mol. Psychiatry (2010) In press :

• Background Reference 02:

  Sugiyama, T., et al. Expert Rev. Mol. Diagn. 8 (4) :435-447 (2008)

• Background Reference 03:

  Inoue, K., et al. Cancer Res. 68 (12) :4487-4490 (2008)

• Background Reference 04:

  Tschan, M.P., et al. Leukemia 22 (5) :1087-1090 (2008)

• Other Product Names:

  Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1

• Tested Applications:

  WB

• Protein ID:

  74762040

• Physical Properties:

  Liquid