Products for Research Use Only

PACRG Antibody

CAT: 0223-59-356Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-59-356Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
135138
Swiss Prot
Q96M98
Accession Number
Q96M98
Host
Rabbit
Reactivity
Human
Immunogen
This PACRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human PACRG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PACRG
NCBI Official Name
Parkin coregulated gene protein
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Wilson, G.R., et al. Fertil. Steril. 93 (7) :2262-2268 (2010)
Background Reference 03
Dagda, R.K., et al. J. Bioenerg. Biomembr. 41 (6) :473-479 (2009)
Background Reference 04
Velez, D.R., et al. Int. J. Tuberc. Lung Dis. 13 (9) :1068-1076 (2009)
Other Product Names
Parkin coregulated gene protein, Molecular chaperone/chaperonin-binding protein, PARK2 coregulated gene protein, PACRG, GLUP
Tested Applications
WB
Protein ID
77416872
Physical Properties
Liquid