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TDP1 Antibody

CAT: 0223-59-353Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-353Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1) . While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
NCBI Gene ID
55775
Swiss Prot
Q9NUW8
Accession Number
Q9NUW8
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-239 amino acids from the Central region of human TDP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TDP1
NCBI Official Name
Tyrosyl-DNA phosphodiesterase 1
NCBI Organism
Homo sapiens
Background Reference 01
Dexheimer, T.S., et al. Nucleic Acids Res. 38 (7) :2444-2452 (2010)
Background Reference 02
Chiang, S.C., et al. Cell Cycle 9 (3) :588-595 (2010)
Background Reference 03
Das, B.B., et al. EMBO J. 28 (23) :3667-3680 (2009)
Background Reference 04
Zhou, T., et al. DNA Repair (Amst.) 8 (8) :901-911 (2009)
Other Product Names
Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, 314-, TDP1
Tested Applications
WB
Protein ID
37999797
Physical Properties
Liquid

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