PDZD3 Antibody

• Background:

  Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]) .

• NCBI Gene ID:

  79849

• Swiss Prot:

  Q86UT5

• Accession Number:

  Q86UT5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  61 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PDZD3

• NCBI Official Name:

  Na (+) /H (+) exchange regulatory cofactor NHE-RF4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zachos, N.C., et al. Cell. Physiol. Biochem. 22 (5-6), 693-704 (2008) :

• Background Reference 02:

  Kato, Y., et al. Mol. Pharmacol. 67 (3) :734-743 (2005)

• Background Reference 03:

  Hegedus, T., et al. Biochem. Biophys. Res. Commun. 302 (3) :454-461 (2003)

• Background Reference 04:

  Scott, R.O., et al. J. Biol. Chem. 277 (25) :22934-22941 (2002)

• Other Product Names:

  Na (+) /H (+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2

• Tested Applications:

  WB

• Protein ID:

  308153467

• Physical Properties:

  Liquid