BTN3A3 Antibody

• Background:

  The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC) -associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]) .[supplied by OMIM].

• NCBI Gene ID:

  10384

• Swiss Prot:

  O00478

• Accession Number:

  O00478

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BTN3A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human BTN3A3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  BTN3A3

• NCBI Official Name:

  Butyrophilin subfamily 3 member A3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Smith, I.A., et al. J. Immunol. 184 (7) :3514-3525 (2010)

• Background Reference 02:

  Zhang, Z., et al. Protein Sci. 13 (10) :2819-2824 (2004)

• Background Reference 03:

  Rhodes, D.A., et al. Genomics 71 (3) :351-362 (2001)

• Background Reference 04:

  Henry, J., et al. Immunol. Today 20 (6) :285-288 (1999)

• Other Product Names:

  Butyrophilin subfamily 3 member A3, BTN3A3, BTF3

• Tested Applications:

  WB

• Physical Properties:

  Liquid