ITGB1BP1 Antibody

• Background:

  The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion.

• NCBI Gene ID:

  9270

• Swiss Prot:

  O14713

• Accession Number:

  O14713

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ITGB1BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-136 amino acids from the Central region of human ITGB1BP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ITGB1BP1

• NCBI Official Name:

  Integrin beta-1-binding protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Brutsch, R., et al. Circ. Res. 107 (5) :592-601 (2010)

• Background Reference 02:

  Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18 (1) :255-259 (2009)

• Background Reference 03:

  Zhang, J., et al. Neurosurgery 63 (3) :571-578 (2008)

• Background Reference 04:

  Furusu, A., et al. J. Cell. Physiol. 210 (3) :703-710 (2007)

• Other Product Names:

  Integrin beta-1-binding protein 1, Integrin cytoplasmic domain-associated protein 1, ICAP-1, ITGB1BP1, ICAP1

• Tested Applications:

  WB

• Physical Properties:

  Liquid