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NARF Antibody

CAT: 0223-59-132Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-132Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
NCBI Gene ID
26502
Swiss Prot
Q9UHQ1
Accession Number
Q9UHQ1
Host
Rabbit
Reactivity
Human
Immunogen
This NARF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-160 amino acids from the Central region of human NARF.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
51 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NARF
NCBI Official Name
Nuclear prelamin A recognition factor
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Moller-Krull, M., et al. J. Mol. Biol. 382 (3) :601-609 (2008)
Background Reference 03
Melzer, D., et al. PLoS Genet. (5), E1000072 (2008) :
Background Reference 04
Lattanzi, G., et al. J. Cell. Biochem. 102 (5) :1149-1159 (2007)
Other Product Names
Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF
Tested Applications
WB
Protein ID
74735021
Physical Properties
Liquid

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