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EXOSC4 Antibody

CAT: 0223-59-063Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-063Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. Required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity. Plays a role in replication-dependent histone mRNA degradation.
NCBI Gene ID
54512
Swiss Prot
Q9NPD3
Accession Number
Q9NPD3
Host
Rabbit
Reactivity
Human
Immunogen
This EXOSC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-96 amino acids from the Central region of human EXOSC4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
EXOSC4
NCBI Official Name
Exosome complex component RRP41
NCBI Organism
Homo sapiens
Background Reference 01
Mullen, T.E., et al. Genes Dev. 22 (1) :50-65 (2008)
Background Reference 02
Van Dijk, E.L., et al. RNA 13 (7) :1027-1035 (2007)
Background Reference 03
Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)
Background Reference 04
Andersen, J.S., et al. Nature 433 (7021) :77-83 (2005)
Other Product Names
Exosome complex component RRP41, Exosome component 4, Ribosomal RNA-processing protein 41, p12A, EXOSC4, RRP41, SKI6
Tested Applications
WB
Protein ID
14285756
Physical Properties
Liquid

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