EXOSC6 Antibody

CAT: 0223-29-489Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-29-489Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly (A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly (A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
NCBI Gene ID
118460
Swiss Prot
Q5RKV6
Accession Number
NP_478126
Host
Rabbit
Reactivity
Human, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human EXOSC6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store EXOSC6 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
30 kDa
Applications Notes
EXOSC6 antibody can be used for detection of EXOSC6 by ELISA at 1:312500. EXOSC6 antibody can be used for detection of EXOSC6 by western blot at 5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
EXOSC6
NCBI Official Name
Exosome component 6
NCBI Organism
Homo sapiens
Background Reference 01
Raijmakers, R., (2002) J. Mol. Biol. 323 (4), 653-663.
Other Product Names
EXOSC6, p11, EAP4, MTR3, Mtr3p, hMtr3p
Tested Applications
ELISA, WB, IHC
Protein ID
17402904
Physical Properties
Liquid

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