MCC Antibody

• Background:

  This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  4163

• Swiss Prot:

  P23508

• Accession Number:

  P23508

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-501 amino acids from the Central region of human MCC.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  93 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MCC

• NCBI Official Name:

  Colorectal mutant cancer protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)

• Background Reference 03:

  Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010)

• Background Reference 04:

  Arnaud, C., et al. FEBS Lett. 583 (14) :2326-2332 (2009)

• Other Product Names:

  Colorectal mutant cancer protein, Protein MCC, MCC

• Tested Applications:

  WB

• Protein ID:

  317373352

• Physical Properties:

  Liquid