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SRRT Antibody

CAT: 0223-59-057Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-59-057Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SRRT acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and RNASEN, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA) ; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
NCBI Gene ID
51593
Swiss Prot
Q9BXP5
Accession Number
Q9BXP5
Host
Rabbit
Reactivity
Human
Immunogen
This SRRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-81 amino acids from the N-terminal region of human SRRT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
101 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SRRT
NCBI Official Name
Serrate RNA effector molecule homolog
NCBI Organism
Homo sapiens
Background Reference 01
Eijgelsheim, M., et al. Hum. Mol. Genet. 19 (19) :3885-3894 (2010)
Background Reference 02
Kiriyama, M., et al. Mol. Cell. Biol. 29 (17) :4729-4741 (2009)
Background Reference 03
Gruber, J.J., et al. Cell 138 (2) :328-339 (2009)
Background Reference 04
Wilson, M.D., et al. Mol. Cell. Biol. 28 (5) :1503-1514 (2008)
Other Product Names
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, SRRT, ARS2, ASR2
Tested Applications
WB
Protein ID
20137457
Physical Properties
Liquid

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