SRRT Antibody

• Background:

  SRRT acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and RNASEN, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA) ; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.

• NCBI Gene ID:

  51593

• Swiss Prot:

  Q9BXP5

• Accession Number:

  Q9BXP5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SRRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-81 amino acids from the N-terminal region of human SRRT.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  101 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SRRT

• NCBI Official Name:

  Serrate RNA effector molecule homolog

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Eijgelsheim, M., et al. Hum. Mol. Genet. 19 (19) :3885-3894 (2010)

• Background Reference 02:

  Kiriyama, M., et al. Mol. Cell. Biol. 29 (17) :4729-4741 (2009)

• Background Reference 03:

  Gruber, J.J., et al. Cell 138 (2) :328-339 (2009)

• Background Reference 04:

  Wilson, M.D., et al. Mol. Cell. Biol. 28 (5) :1503-1514 (2008)

• Other Product Names:

  Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, SRRT, ARS2, ASR2

• Tested Applications:

  WB

• Protein ID:

  20137457

• Physical Properties:

  Liquid