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GPNMB Antibody

CAT: 0223-59-048Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-048Size:400 µL
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Background
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
10457
Swiss Prot
Q14956
Accession Number
Q14956
Host
Rabbit
Reactivity
Human
Immunogen
This GPNMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-569 amino acids from the C-terminal region of human GPNMB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
64 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:500
Symbol
GPNMB
NCBI Official Name
Transmembrane glycoprotein NMB
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Williams, M.D., et al. Melanoma Res. 20 (3) :184-190 (2010)
Background Reference 03
Hoashi, T., et al. FASEB J. 24 (5) :1616-1629 (2010)
Background Reference 04
Rose, A.A., et al. Clin. Cancer Res. 16 (7) :2147-2156 (2010)
Other Product Names
Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB
Tested Applications
WB
Protein ID
61252504
Physical Properties
Liquid

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