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HERPUD1 Antibody

CAT: 0223-59-043Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-043Size:400 µL
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Background
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq].
NCBI Gene ID
9709
Swiss Prot
Q15011
Accession Number
Q15011
Host
Rabbit
Reactivity
Human
Immunogen
This HERPUD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human HERPUD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HERPUD1
NCBI Official Name
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
NCBI Organism
Homo sapiens
Background Reference 01
Hirabayashi, Y., et al. J. Immunol. 184 (6) :3276-3283 (2010)
Background Reference 02
McLaughlin, M., et al. J. Biol. Chem. 285 (10) :6960-6969 (2010)
Background Reference 03
Zabaneh, D., et al. PLoS ONE (8), E11961 (2010) :
Background Reference 04
Ridker, P.M., et al. Circ Cardiovasc Genet 2 (1) :26-33 (2009)
Other Product Names
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, Methyl methanesulfonate (MMF) -inducible fragment protein 1, HERPUD1, HERP, KIAA0025, MIF1
Tested Applications
WB
Protein ID
3123034
Physical Properties
Liquid

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