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PDE4A Antibody

CAT: 0223-59-005Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-005Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]) .
NCBI Gene ID
5141
Swiss Prot
P27815
Accession Number
P27815
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PDE4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human PDE4A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
98 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PDE4A
NCBI Official Name
CAMP-specific 3',5'-cyclic phosphodiesterase 4A
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Selige, J., et al. J. Cell. Physiol. 223 (2) :317-326 (2010)
Background Reference 03
Bjorgo, E., et al. Mol. Cell. Biol. 30 (7) :1660-1672 (2010)
Background Reference 04
Singh, D., et al. Respir. Res. 11, 26 (2010) :
Other Product Names
CAMP-specific 3',5'-cyclic phosphodiesterase 4A, DPDE2, PDE46, PDE4A, DPDE2
Tested Applications
WB
Protein ID
116242706
Physical Properties
Liquid

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