CBX2 Antibody

• Background:

  This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

• NCBI Gene ID:

  84733

• Swiss Prot:

  Q14781

• Accession Number:

  Q14781

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of human CBX2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CBX2

• NCBI Official Name:

  Chromobox protein homolog 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Biason-Lauber, A., et al. Am. J. Hum. Genet. 84 (5) :658-663 (2009)

• Background Reference 02:

  Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)

• Background Reference 03:

  Agrawal, N., et al. PLoS ONE (12), E4032 (2008) :

• Background Reference 04:

  Garcia, E., et al. EMBO J. 18 (12) :3404-3418 (1999)

• Other Product Names:

  Chromobox protein homolog 2, CBX2

• Tested Applications:

  WB

• Protein ID:

  77416853

• Physical Properties:

  Liquid