CBX5 Antibody

CAT: 0223-57-266Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-266Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
NCBI Gene ID
23468
Swiss Prot
P45973
Accession Number
P45973
Host
Rabbit
Reactivity
Human
Immunogen
This CBX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human CBX5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CBX5
NCBI Official Name
Chromobox protein homolog 5
NCBI Organism
Homo sapiens
Background Reference 01
Nozawa, R.S., et al. Nat. Cell Biol. 12 (7) :719-727 (2010)
Background Reference 02
Zeng, W., et al. Epigenetics 5 (4) :287-292 (2010)
Background Reference 03
Emelyanov, A.V., et al. J. Biol. Chem. 285 (20) :15027-15037 (2010)
Background Reference 04
Kiyomitsu, T., et al. J. Cell Biol. 188 (6) :791-807 (2010)
Other Product Names
Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, CBX5, HP1A
Tested Applications
WB
Protein ID
1170338
Physical Properties
Liquid

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