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CLP1 Antibody

CAT: 0223-58-976Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-976Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC) . However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
NCBI Gene ID
10978
Swiss Prot
Q92989
Accession Number
Q92989
Host
Rabbit
Reactivity
Human
Immunogen
This CLP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the C-terminal region of human CLP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Monkey, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CLP1
NCBI Official Name
Polyribonucleotide 5'-hydroxyl-kinase Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}
NCBI Organism
Homo sapiens
Background Reference 01
Ramirez, A., et al. RNA 14 (9) :1737-1745 (2008)
Background Reference 02
Weitzer, S., et al. Nature 447 (7141) :222-226 (2007)
Background Reference 03
Paushkin, S.V., et al. Cell 117 (3) :311-321 (2004)
Background Reference 04
Zhou, Z., et al. Nature 419 (6903) :182-185 (2002)
Other Product Names
Polyribonucleotide 5'-hydroxyl-kinase Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}, 27178 {ECO:0000255|HAMAP-Rule:MF_03035}, Polyadenylation factor Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}, Polynucleotide kinase Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}, Pre-mRNA cleavage complex II protein Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}, CLP1 {ECO:0000255|HAMAP-Rule:MF_03035}, HEAB
Tested Applications
WB
Protein ID
13431366
Physical Properties
Liquid

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