CLPB Antibody

CAT: 0223-23-800Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-23-800Size:100 µL
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Background
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
81570
Swiss Prot
Q9H078
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 458-707 of human CLPB (NP_110440.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 79kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
CLPB
Positive Control 2
MCF7
Positive Control 3
Mouse brain
Positive Control 4
Rat brain
NCBI Official Name
ClpB caseinolytic peptidase B homolog (E. coli)
NCBI Organism
Homo sapiens
Other Product Names
CLPB, FLJ13152, HSP78, SKD3
Tested Applications
WB
Physical Properties
Liquid

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