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Bmp1 Antibody

CAT: 0223-58-970Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-970Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.
NCBI Gene ID
649
Swiss Prot
P13497
Accession Number
P13497
Host
Rabbit
Reactivity
Mouse
Immunogen
This Bmp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 957-986 amino acids from the C-terminal region of human Bmp1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
111 kDa
Fragment
Rabbit Ig
Symbol
BMP1
NCBI Official Name
Bone morphogenetic protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Leighton, M., et al., J. Biol. Chem. 278 (20) :18478-18484 (2003) .
Background Reference 02
Hartigan, N., et al., J. Biol. Chem. 278 (20) :18045-18049 (2003) .
Background Reference 03
Garrigue-Antar, L., et al., J. Biol. Chem. 277 (45) :43327-43334 (2002) .
Background Reference 04
Rattenholl, A., et al., J. Biol. Chem. 277 (29) :26372-26378 (2002) .
Other Product Names
Bone morphogenetic protein 1, BMP-1, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC
Tested Applications
WB, IHC-P
Protein ID
13124688
Physical Properties
Liquid

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