ERVWE1 Antibody

• Background:

  Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

• NCBI Gene ID:

  30816

• Swiss Prot:

  Q9UQF0

• Accession Number:

  Q9UQF0

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ERVWE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-521 amino acids from the C-terminal region of human ERVWE1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ERVW-1

• NCBI Official Name:

  Syncytin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :

• Background Reference 02:

  Oppelt, P., et al. Gynecol. Endocrinol. 25 (11) :741-747 (2009)

• Background Reference 03:

  Gimenez, J., et al. DNA Res. 16 (4) :195-211 (2009)

• Background Reference 04:

  Larsen, J.M., et al. Cancer Lett. 280 (1) :44-49 (2009)

• Other Product Names:

  Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1

• Tested Applications:

  WB

• Protein ID:

  47605755

• Physical Properties:

  Liquid