PAX2 Antibody

• Background:

  PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.

• NCBI Gene ID:

  5076

• Swiss Prot:

  Q02962

• Accession Number:

  Q02962

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PAX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of human PAX2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PAX2

• NCBI Official Name:

  Paired box protein Pax-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Monte, N.M., et al. Cancer Res. 70 (15) :6225-6232 (2010)

• Background Reference 02:

  Ozcan, A., et al. Arch. Pathol. Lab. Med. 134 (8) :1121-1129 (2010)

• Background Reference 03:

  Quick, C.M., et al. Hum. Pathol. 41 (8) :1145-1149 (2010)

• Background Reference 04:

  Martinovic-Bouriel, J., et al. Am. J. Med. Genet.152A (4), 830-835 (2010) :

• Other Product Names:

  Paired box protein Pax-2, PAX2

• Tested Applications:

  WB

• Protein ID:

  223590261

• Physical Properties:

  Liquid