KRT6A Antibody

CAT: 0223-58-847Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-847Size:400 µL
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Background
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq].
NCBI Gene ID
3853
Swiss Prot
P02538
Accession Number
P02538
Host
Rabbit
Reactivity
Human
Immunogen
This KRT6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the N-terminal region of human KRT6A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
KRT6A
NCBI Official Name
Keratin, type II cytoskeletal 6A
NCBI Organism
Homo sapiens
Background Reference 01
Dereure, O. Ann Dermatol Venereol 137 (5) :423-424 (2010)
Background Reference 02
Trost, A., et al. Mech. Ageing Dev. 131 (5) :346-353 (2010)
Background Reference 03
Yang, L., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 (1) :66-68 (2010)
Background Reference 04
Millar, E.K., et al. J. Clin. Oncol. 27 (28) :4701-4708 (2009)
Other Product Names
Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D
Tested Applications
WB
Protein ID
1346344
Physical Properties
Liquid

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