KRT6A Antibody

• Background:

  The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq].

• NCBI Gene ID:

  3853

• Swiss Prot:

  P02538

• Accession Number:

  P02538

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KRT6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the N-terminal region of human KRT6A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KRT6A

• NCBI Official Name:

  Keratin, type II cytoskeletal 6A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dereure, O. Ann Dermatol Venereol 137 (5) :423-424 (2010)

• Background Reference 02:

  Trost, A., et al. Mech. Ageing Dev. 131 (5) :346-353 (2010)

• Background Reference 03:

  Yang, L., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 (1) :66-68 (2010)

• Background Reference 04:

  Millar, E.K., et al. J. Clin. Oncol. 27 (28) :4701-4708 (2009)

• Other Product Names:

  Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D

• Tested Applications:

  WB

• Protein ID:

  1346344

• Physical Properties:

  Liquid