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SEMA6D Antibody

CAT: 0223-58-787Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-787Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq].
NCBI Gene ID
80031
Swiss Prot
Q8NFY4
Accession Number
Q8NFY4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SEMA6D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human SEMA6D.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
120 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SEMA6D
NCBI Official Name
Semaphorin-6D
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Background Reference 03
Stokowski, R.P., et al. Am. J. Hum. Genet. 81 (6) :1119-1132 (2007)
Background Reference 04
Zhao, X.Y., et al. World J. Gastroenterol. 12 (45) :7388-7390 (2006)
Other Product Names
Semaphorin-6D, SEMA6D, KIAA1479
Tested Applications
WB
Protein ID
74715611
Physical Properties
Liquid

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