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SEMA4A Antibody

CAT: 0223-58-716Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-716Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF) -mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10) . Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI Gene ID
64218
Swiss Prot
Q9H3S1
Accession Number
Q9H3S1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SEMA4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human SEMA4A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
84 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:500
Symbol
SEMA4A
NCBI Official Name
Semaphorin-4A
NCBI Organism
Homo sapiens
Background Reference 01
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 02
Schmidt-Kastner, R., et al. Mol. Vis. 14, 125-135 (2008) :
Background Reference 03
Toyofuku, T., et al. EMBO J. 26 (5) :1373-1384 (2007)
Background Reference 04
Abid, A., et al. J. Med. Genet. 43 (4) :378-381 (2006)
Other Product Names
Semaphorin-4A, Semaphorin-B, Sema B, SEMA4A, SEMAB, SEMB
Tested Applications
WB
Protein ID
29840871
Physical Properties
Liquid

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