BSDC1 Antibody

• Background:

  BSDC1 is a 430 amino acid protein encoded by a gene mapping to chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

• NCBI Gene ID:

  55108

• Swiss Prot:

  Q9NW68

• Accession Number:

  Q9NW68

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BSDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 397-425 amino acids from the C-terminal region of human BSDC1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  47 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  BSDC1

• NCBI Official Name:

  BSD domain-containing protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)

• Background Reference 02:

  Fu, G.K., et al. Genomics 84 (1) :205-210 (2004)

• Background Reference 03:

  Clark, H.F., et al. Genome Res. 13 (10) :2265-2270 (2003)

• Other Product Names:

  BSD domain-containing protein 1, BSDC1

• Tested Applications:

  WB

• Protein ID:

  74753009

• Physical Properties:

  Liquid