PHEX Antibody

CAT: 0223-58-750Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-750Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets.
NCBI Gene ID
5251
Swiss Prot
P78562
Accession Number
P78562
Host
Rabbit
Reactivity
Human
Immunogen
This PHEX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the C-terminal region of human PHEX.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
86 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PHEX
NCBI Official Name
Phosphate-regulating neutral endopeptidase
NCBI Organism
Homo sapiens
Background Reference 01
Majewski, P.M., et al. J. Biol. Chem. 285 (45) :34828-34838 (2010)
Background Reference 02
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Background Reference 03
Clausmeyer, S., et al. Calcif. Tissue Int. 85 (3) :211-220 (2009)
Background Reference 04
Gaucher, C., et al. Hum. Genet. 125 (4) :401-411 (2009)
Other Product Names
Phosphate-regulating neutral endopeptidase, 3424-, Metalloendopeptidase homolog PEX, Vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein, HYP, PHEX, PEX
Tested Applications
WB
Protein ID
2499917
Physical Properties
Liquid

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