PHEX Antibody

• Background:

  The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets.

• NCBI Gene ID:

  5251

• Swiss Prot:

  P78562

• Accession Number:

  P78562

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PHEX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the C-terminal region of human PHEX.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  86 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PHEX

• NCBI Official Name:

  Phosphate-regulating neutral endopeptidase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Majewski, P.M., et al. J. Biol. Chem. 285 (45) :34828-34838 (2010)

• Background Reference 02:

  Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :

• Background Reference 03:

  Clausmeyer, S., et al. Calcif. Tissue Int. 85 (3) :211-220 (2009)

• Background Reference 04:

  Gaucher, C., et al. Hum. Genet. 125 (4) :401-411 (2009)

• Other Product Names:

  Phosphate-regulating neutral endopeptidase, 3424-, Metalloendopeptidase homolog PEX, Vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein, HYP, PHEX, PEX

• Tested Applications:

  WB

• Protein ID:

  2499917

• Physical Properties:

  Liquid