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ATL1 Antibody

CAT: 0223-58-730Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-730Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
NCBI Gene ID
51062
Swiss Prot
Q8WXF7
Accession Number
Q8WXF7
Host
Rabbit
Reactivity
Human
Immunogen
This ATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-504 amino acids from the C-terminal region of human ATL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
64 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ATL1
NCBI Official Name
Atlastin-1
NCBI Organism
Homo sapiens
Background Reference 01
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18 (7) :815-820 (2010)
Background Reference 02
Park, S.H., et al. J. Clin. Invest. 120 (4) :1097-1110 (2010)
Background Reference 03
Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)
Background Reference 04
De Leva, M.F., et al. J. Neurol. 257 (3) :328-331 (2010)
Other Product Names
Atlastin-1, 365-, Brain-specific GTP-binding protein, GTP-binding protein 3, GBP-3, hGBP3, Guanine nucleotide-binding protein 3, Spastic paraplegia 3 protein A, ATL1, GBP3, SPG3A
Tested Applications
WB
Protein ID
37999727
Physical Properties
Liquid

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