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RCAN1 Antibody

CAT: 0223-58-724Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-724Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
NCBI Gene ID
1827
Swiss Prot
P53805
Accession Number
P53805
Host
Rabbit
Reactivity
Human
Immunogen
This RCAN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-68 amino acids from the N-terminal region of human RCAN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Symbol
RCAN1
NCBI Official Name
Calcipressin-1
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Tam, G.W., et al. Biochem. Soc. Trans. 38 (2) :445-451 (2010)
Background Reference 03
Lee, M.Y., et al. Hum. Mol. Genet. 19 (3) :468-479 (2010)
Background Reference 04
Sales, K.J., et al. Am. J. Pathol. 176 (1) :435-445 (2010)
Other Product Names
Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1
Tested Applications
WB, IF
Protein ID
215274235
Physical Properties
Liquid

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