DRD2 Antibody

• Background:

  This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

• NCBI Gene ID:

  1813

• Swiss Prot:

  P14416

• Accession Number:

  P14416

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DRD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the C-terminal region of human DRD2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  51 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:2000

• Symbol:

  DRD2

• NCBI Official Name:

  D (2) dopamine receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Verma, V., et al. J. Biol. Chem. 285 (45) :35092-35103 (2010)

• Background Reference 02:

  Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401 (4) :605-610 (2010)

• Background Reference 03:

  Stelzel, C., et al. J. Neurosci. 30 (42) :14205-14212 (2010)

• Background Reference 04:

  Huang, H.Y., et al. J. Formos. Med. Assoc. 109 (10) :736-739 (2010)

• Other Product Names:

  D (2) dopamine receptor, Dopamine D2 receptor, DRD2

• Tested Applications:

  WB

• Protein ID:

  118206

• Physical Properties:

  Liquid