DRD2 Antibody

CAT: 0223-58-687Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-687Size:400 µL
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Background
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
NCBI Gene ID
1813
Swiss Prot
P14416
Accession Number
P14416
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DRD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the C-terminal region of human DRD2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
51 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
DRD2
NCBI Official Name
D (2) dopamine receptor
NCBI Organism
Homo sapiens
Background Reference 01
Verma, V., et al. J. Biol. Chem. 285 (45) :35092-35103 (2010)
Background Reference 02
Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401 (4) :605-610 (2010)
Background Reference 03
Stelzel, C., et al. J. Neurosci. 30 (42) :14205-14212 (2010)
Background Reference 04
Huang, H.Y., et al. J. Formos. Med. Assoc. 109 (10) :736-739 (2010)
Other Product Names
D (2) dopamine receptor, Dopamine D2 receptor, DRD2
Tested Applications
WB
Protein ID
118206
Physical Properties
Liquid

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