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PTPN22 Antibody

CAT: 0223-58-674Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-674Size:400 µL
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Background
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
NCBI Gene ID
26191
Swiss Prot
Q9Y2R2
Accession Number
Q9Y2R2
Host
Rabbit
Reactivity
Human
Immunogen
This PTPN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-691 amino acids from the C-terminal region of human PTPN22.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
92 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PTPN22
NCBI Official Name
Tyrosine-protein phosphatase non-receptor type 22
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Andersen, M.K., et al. Diabetes Care 33 (9) :2062-2064 (2010)
Background Reference 03
Bianco, B., et al. Scand. J. Immunol. 72 (3) :256-259 (2010)
Background Reference 04
Pradhan, V., et al.Postgrad Med 56 (3) :239-242 (2010)
Other Product Names
Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP, PTPN22, PTPN8
Tested Applications
WB
Protein ID
20139861
Physical Properties
Liquid

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