EPOR Antibody

• Background:

  This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  2057

• Swiss Prot:

  P19235

• Accession Number:

  P19235

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EPOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human EPOR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  55 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  EPOR

• NCBI Official Name:

  Erythropoietin receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lim, A.C., et al. Biochemistry 49 (18) :3797-3804 (2010)

• Background Reference 02:

  Perrotta, S., et al. PLoS ONE (8), E12015 (2010) :

• Background Reference 03:

  Khankin, E.V., et al. PLoS ONE (2), E9246 (2010) :

• Background Reference 04:

  Wincewicz, A., et al. Folia Histochem. Cytobiol. 47 (3) :425-430 (2009)

• Other Product Names:

  Erythropoietin receptor, EPO-R, EPOR

• Tested Applications:

  WB, IF, Flow

• Protein ID:

  119524

• Physical Properties:

  Liquid