AKR1D1 Antibody

• Background:

  The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta (4) -3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.

• NCBI Gene ID:

  6718

• Swiss Prot:

  P51857

• Accession Number:

  P51857

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AKR1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the Central region of human AKR1D1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  AKR1D1

• NCBI Official Name:

  3-oxo-5-beta-steroid 4-dehydrogenase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :

• Background Reference 02:

  Drury, J.E., et al. J. Biol. Chem. 285 (32) :24529-24537 (2010)

• Background Reference 03:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04:

  Ueki, I., et al. J. Gastroenterol. Hepatol. 24 (5) :776-785 (2009)

• Other Product Names:

  3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta (4) -3-ketosteroid 5-beta-reductase, Delta (4) -3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1

• Tested Applications:

  WB

• Protein ID:

  1703007

• Physical Properties:

  Liquid