H2BFWT Antibody

• Background:

  Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.

• NCBI Gene ID:

  158983

• Swiss Prot:

  Q7Z2G1

• Accession Number:

  Q7Z2G1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This H2BFWT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-88 amino acids from the Central region of human H2BFWT.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  20 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  H2BFWT

• NCBI Official Name:

  Histone H2B type W-T

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lee, J., et al. J. Cell. Mol. Med. 13 (8B), 1942-1951 (2009) :

• Background Reference 02:

  Boulard, M., et al. Mol. Cell. Biol. 26 (4) :1518-1526 (2006)

• Background Reference 03:

  Churikov, D., et al. Genomics 84 (4) :745-756 (2004)

• Background Reference 04:

  Churikov, D., et al. Cytogenet. Genome Res. 105 (2-4), 203-214 (2004) :

• Other Product Names:

  Histone H2B type W-T, H2B histone family member W testis-specific, H2BFWT

• Tested Applications:

  WB

• Protein ID:

  223590216

• Physical Properties:

  Liquid