DEF6 Antibody

• Background:

  DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]) .

• NCBI Gene ID:

  50619

• Swiss Prot:

  Q9H4E7

• Accession Number:

  Q9H4E7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-528 amino acids from the C-terminal region of human DEF6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  74 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DEF6

• NCBI Official Name:

  Differentially expressed in FDCP 6 homolog

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)

• Background Reference 02:

  Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1356-1361 (2010)

• Background Reference 03:

  Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :

• Background Reference 04:

  Zhang, Z., et al. Cancer Epidemiol 33 (2) :130-136 (2009)

• Other Product Names:

  Differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP

• Tested Applications:

  WB

• Protein ID:

  74761430

• Physical Properties:

  Liquid