CCRL2 Antibody

• Background:

  This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.

• NCBI Gene ID:

  9034

• Swiss Prot:

  O00421

• Accession Number:

  O00421

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CCRL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the Central region of human CCRL2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  40 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CCRL2

• NCBI Official Name:

  C-C chemokine receptor-like 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 02:

  Dubois, P.C., et al. Nat. Genet. 42 (4) :295-302 (2010)

• Background Reference 03:

  Leick, M., et al. Immunology 129 (4) :536-546 (2010)

• Background Reference 04:

  Segat, L., et al. Vaccine 28 (10) :2201-2206 (2010)

• Other Product Names:

  C-C chemokine receptor-like 2, Chemokine receptor CCR11, Chemokine receptor X, Putative MCP-1 chemokine receptor, CCRL2, CCR11, CCR6, CKRX, CRAM, HCR

• Tested Applications:

  WB

• Physical Properties:

  Liquid