GH2 Antibody

• Background:

  The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq].

• NCBI Gene ID:

  2689

• Swiss Prot:

  P01242

• Accession Number:

  P01242

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human GH2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GH2

• NCBI Official Name:

  Growth hormone variant

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  McElholm, A.R., et al. Gastroenterology 139 (1) :204-212 (2010)

• Background Reference 02:

  De Jesus Romero-Prado, M.M., et al. Gene 452 (1) :7-15 (2010)

• Background Reference 03:

  Christiansen, M. Prenat. Diagn. 29 (13) :1249-1255 (2009)

• Background Reference 04:

  Zeck, W., et al. Pediatr. Res. 63 (4) :353-357 (2008)

• Other Product Names:

  Growth hormone variant, GH-V, Growth hormone 2, Placenta-specific growth hormone, GH2

• Tested Applications:

  WB

• Physical Properties:

  Liquid