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GH2 Antibody

CAT: 0223-58-499Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-499Size:400 µL
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Background
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq].
NCBI Gene ID
2689
Swiss Prot
P01242
Accession Number
P01242
Host
Rabbit
Reactivity
Human
Immunogen
This GH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human GH2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GH2
NCBI Official Name
Growth hormone variant
NCBI Organism
Homo sapiens
Background Reference 01
McElholm, A.R., et al. Gastroenterology 139 (1) :204-212 (2010)
Background Reference 02
De Jesus Romero-Prado, M.M., et al. Gene 452 (1) :7-15 (2010)
Background Reference 03
Christiansen, M. Prenat. Diagn. 29 (13) :1249-1255 (2009)
Background Reference 04
Zeck, W., et al. Pediatr. Res. 63 (4) :353-357 (2008)
Other Product Names
Growth hormone variant, GH-V, Growth hormone 2, Placenta-specific growth hormone, GH2
Tested Applications
WB
Physical Properties
Liquid

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