SIGLEC12 Antibody

• Background:

  Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.

• NCBI Gene ID:

  89858

• Swiss Prot:

  Q96PQ1

• Accession Number:

  Q96PQ1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This SIGLEC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 565-595 amino acids from the C-terminal region of human SIGLEC12.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SIGLEC12

• NCBI Official Name:

  Sialic acid-binding Ig-like lectin 12

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Angata, T., J. Biol. Chem. 276 (43), 40282-40287 (2001)

• Background Reference 02:

  Yu, Z., J. Biol. Chem. 276 (26), 23816-23824 (2001)

• Background Reference 03:

  Foussias, G., Biochem. Biophys. Res. Commun. 284 (4), 887-899 (2001)

• Other Product Names:

  Sialic acid-binding Ig-like lectin 12, Siglec-12, Sialic acid-binding Ig-like lectin-like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG

• Tested Applications:

  WB, IHC-P

• Protein ID:

  25009264

• Physical Properties:

  Liquid