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SIGLEC12 Antibody

CAT: 0223-58-424Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-424Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.
NCBI Gene ID
89858
Swiss Prot
Q96PQ1
Accession Number
Q96PQ1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SIGLEC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 565-595 amino acids from the C-terminal region of human SIGLEC12.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Symbol
SIGLEC12
NCBI Official Name
Sialic acid-binding Ig-like lectin 12
NCBI Organism
Homo sapiens
Background Reference 01
Angata, T., J. Biol. Chem. 276 (43), 40282-40287 (2001)
Background Reference 02
Yu, Z., J. Biol. Chem. 276 (26), 23816-23824 (2001)
Background Reference 03
Foussias, G., Biochem. Biophys. Res. Commun. 284 (4), 887-899 (2001)
Other Product Names
Sialic acid-binding Ig-like lectin 12, Siglec-12, Sialic acid-binding Ig-like lectin-like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG
Tested Applications
WB, IHC-P
Protein ID
25009264
Physical Properties
Liquid

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