CC2D1A Antibody

• Background:

  CC2D1A is a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.

• NCBI Gene ID:

  54862

• Swiss Prot:

  Q6P1N0

• Accession Number:

  Q6P1N0

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CC2D1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the N-terminal region of human CC2D1A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  104 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CC2D1A

• NCBI Official Name:

  Coiled-coil and C2 domain-containing protein 1A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhao, M., et al. J. Biol. Chem. 285 (32) :24372-24380 (2010)

• Background Reference 02:

  Nakamura, A., et al. Biochem. Biophys. Res. Commun. 393 (4) :872-876 (2010)

• Background Reference 03:

  Nakamura, A., et al. J. Cell Biol. 187 (5) :607-614 (2009)

• Background Reference 04:

  McKay, G.J., et al. Invest. Ophthalmol. Vis. Sci. 50 (2) :533-539 (2009)

• Other Product Names:

  Coiled-coil and C2 domain-containing protein 1A, Akt kinase-interacting protein 1, Five prime repressor element under dual repression-binding protein 1, FRE under dual repression-binding protein 1, Freud-1, Putative NF-kappa-B-activating protein 023N, CC2D1A, AKI1

• Tested Applications:

  WB

• Protein ID:

  74737148

• Physical Properties:

  Liquid