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SIGLEC6 Antibody

CAT: 0223-58-355Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-355Size:400 µL
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Background
SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM) . This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.
NCBI Gene ID
946
Swiss Prot
O43699
Accession Number
O43699
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SIGLEC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human SIGLEC6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Symbol
SIGLEC6
NCBI Official Name
Sialic acid-binding Ig-like lectin 6
NCBI Organism
Homo sapiens
Background Reference 01
Patel, N., et al., J. Biol. Chem. 274 (32) :22729-22738 (1999) .
Background Reference 02
Takei, Y., et al., Cytogenet. Cell Genet. 78 (3-4), 295-300 (1997) .
Background Reference 03
Patel, N., et al., J. Biol. Chem. 274, 28058-28058 (1999) .
Other Product Names
Sialic acid-binding Ig-like lectin 6, Siglec-6, CD33 antigen-like 1, CDw327, Obesity-binding protein 1, OB-BP1, CD327, SIGLEC6, CD33L, CD33L1, OBBP1
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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