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SIGLEC8 Antibody

CAT: 0223-58-370Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-370Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM) . This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
NCBI Gene ID
27181
Swiss Prot
Q9NYZ4
Accession Number
Q9NYZ4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SIGLEC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-406 amino acids from the C-terminal region of human SIGLEC8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Symbol
SIGLEC8
NCBI Official Name
Sialic acid-binding Ig-like lectin 8
NCBI Organism
Homo sapiens
Background Reference 01
Foussias, G., et al., Biochem. Biophys. Res. Commun. 278 (3) :775-781 (2000) .
Background Reference 02
Floyd, H., et al., J. Biol. Chem. 275 (2) :861-866 (2000) .
Background Reference 03
Kikly, K.K., et al., J. Allergy Clin. Immunol. 105 (6 Pt 1), 1093-1100 (2000) .
Other Product Names
Sialic acid-binding Ig-like lectin 8, Siglec-8, Sialoadhesin family member 2, SAF-2, SIGLEC8, SAF2
Tested Applications
WB, IHC-P
Protein ID
25009268
Physical Properties
Liquid

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