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L1CAM Antibody

CAT: 0223-58-338Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-338Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) . Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
NCBI Gene ID
3897
Swiss Prot
P32004
Accession Number
P32004
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This L1CAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1154-1182 amino acids from the C-terminal region of human L1CAM.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
140 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
L1CAM
NCBI Official Name
Neural cell adhesion molecule L1
NCBI Organism
Homo sapiens
Background Reference 01
Schafer, M.K., et al. FEBS Lett. 584 (21) :4475-4480 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010) :
Background Reference 04
Schafer, M.K., et al. Cell. Mol. Life Sci. 67 (14) :2425-2437 (2010)
Other Product Names
Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5
Tested Applications
WB
Protein ID
1705571
Physical Properties
Liquid

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