VPS45 Antibody

• Background:

  Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. [provided by RefSeq].

• NCBI Gene ID:

  11311

• Swiss Prot:

  Q9NRW7

• Accession Number:

  Q9NRW7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This VPS45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 461-489 amino acids from the C-terminal region of human VPS45.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  VPS45

• NCBI Official Name:

  Vacuolar protein sorting-associated protein 45

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rahajeng, J., et al. Exp. Cell Res. 316 (5) :859-874 (2010)

• Background Reference 02:

  Kim, B.Y., et al. Biochem. Biophys. Res. Commun. 311 (3) :577-582 (2003)

• Background Reference 03:

  Dulubova, I., et al. EMBO J. 21 (14) :3620-3631 (2002)

• Background Reference 04:

  De Renzis, S., et al. Nat. Cell Biol. 4 (2) :124-133 (2002)

• Other Product Names:

  Vacuolar protein sorting-associated protein 45, h-VPS45, hlVps45, VPS45, VPS45A, VPS45B

• Tested Applications:

  WB

• Protein ID:

  23396937

• Physical Properties:

  Liquid