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VPS4B Antibody

CAT: 0223-57-287Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-287Size:400 µL
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Background
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq].
NCBI Gene ID
9525
Swiss Prot
O75351
Accession Number
O75351
Host
Rabbit
Reactivity
Human
Immunogen
This VPS4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-332 amino acids from the C-terminal region of human VPS4B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
49 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
VPS4B
NCBI Official Name
Vacuolar protein sorting-associated protein 4B
NCBI Organism
Homo sapiens
Background Reference 01
Morita, E., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (29) :12889-12894 (2010)
Background Reference 02
McDonough, C.W., et al. Hum. Genet. (2009) In press :
Background Reference 03
Bruce, E.A., et al. Virology 390 (2) :268-278 (2009)
Background Reference 04
Inoue, M., et al. Traffic 9 (12) :2180-2189 (2008)
Other Product Names
Vacuolar protein sorting-associated protein 4B, Cell migration-inducing gene 1 protein, Suppressor of K (+) transport growth defect 1, Protein SKD1, VPS4B, SKD1, VPS42
Tested Applications
WB
Physical Properties
Liquid

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