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Mouse Stk3 Antibody

CAT: 0223-58-259Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-259Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.
NCBI Gene ID
56274
Swiss Prot
Q9JI10
Accession Number
Q9JI10
Host
Rabbit
Reactivity
Human
Immunogen
This Mouse Stk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of mouse Stk3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Stk3
NCBI Official Name
Serine/threonine-protein kinase 3
NCBI Organism
Mus musculus
Background Reference 01
Oh, H.J., et al. Curr. Biol. 20 (5) :416-422 (2010)
Background Reference 02
Lu, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (4) :1437-1442 (2010)
Background Reference 03
Song, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (4) :1431-1436 (2010)
Background Reference 04
Zhou, D., et al. Cancer Cell 16 (5) :425-438 (2009)
Other Product Names
Serine/threonine-protein kinase 3, Mammalian STE20-like protein kinase 2, MST-2, STE20-like kinase MST2, Serine/threonine-protein kinase 3 36kDa subunit, MST2/N, Serine/threonine-protein kinase 3 20kDa subunit, MST2/C, Stk3, Mess1, Mst2
Tested Applications
WB
Physical Properties
Liquid

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