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Mouse Irf3 Antibody

CAT: 0223-60-856Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-856Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity) .
NCBI Gene ID
54131
Swiss Prot
P70671
Accession Number
P70671
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Inflammasomes
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Irf3
NCBI Official Name
Interferon regulatory factor 3
NCBI Organism
Mus musculus
Background Reference 01
Marichal, T., et al. J. Allergy Clin. Immunol. 126 (4) :836-844 (2010)
Background Reference 02
Menachery, V.D., et al. J. Virol. 84 (19) :9685-9694 (2010)
Background Reference 03
Carrigan, S.O., et al. J. Immunol. 185 (6) :3602-3609 (2010)
Background Reference 04
Wang, J., et al. J. Immunol. 185 (3) :1720-1729 (2010)
Other Product Names
Interferon regulatory factor 3, IRF-3, Irf3
Tested Applications
WB
Physical Properties
Liquid

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