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C4BPB Antibody

CAT: 0223-58-233Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-233Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
NCBI Gene ID
725
Swiss Prot
P20851
Accession Number
P20851
Host
Rabbit
Reactivity
Human
Immunogen
This C4BPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human C4BPB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
C4BPB
NCBI Official Name
C4b-binding protein beta chain
NCBI Organism
Homo sapiens
Background Reference 01
Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Buil, A., et al. Blood 115 (23) :4644-4650 (2010)
Background Reference 04
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1356-1361 (2010)
Other Product Names
C4b-binding protein beta chain, C4BPB
Tested Applications
WB
Protein ID
115213
Physical Properties
Liquid

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