LTBR Antibody

• Background:

  The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta) . The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.

• NCBI Gene ID:

  4055

• Swiss Prot:

  P36941

• Accession Number:

  P36941

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This LTBR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human LTBR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  47 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  LTBR

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily member 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cheung, T.C., et al. J. Immunol. 185 (3) :1949-1958 (2010)

• Background Reference 02:

  Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)

• Background Reference 03:

  Sanjo, H., et al. J. Biol. Chem. 285 (22) :17148-17155 (2010)

• Background Reference 04:

  Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1356-1361 (2010)

• Other Product Names:

  Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor type III, TNF-RIII, TNFR-III, LTBR, D12S370, TNFCR, TNFR3, TNFRSF3

• Tested Applications:

  WB

• Protein ID:

  549090

• Physical Properties:

  Liquid