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GCAP1 Antibody

CAT: 0223-58-190Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-190Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Guanylate cyclase-activating protein is a l Ca (2+) -binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90% similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca (2+) -binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
NCBI Gene ID
2978
Swiss Prot
P43080
Accession Number
P43080
Host
Rabbit
Reactivity
Human
Immunogen
This GCAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-191 amino acids from the C-terminal region of human GCAP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
23 kDa
Fragment
Rabbit Ig
Symbol
GUCA1A
NCBI Official Name
Guanylyl cyclase-activating protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Pennesi, M.E., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (11) :6783-6788 (2003) .
Background Reference 02
Payne, A.M., et al., Hum. Mol. Genet. 7 (2) :273-277 (1998) .
Background Reference 03
Subbaraya, I., et al., J. Biol. Chem. 269 (49) :31080-31089 (1994) .
Other Product Names
Guanylyl cyclase-activating protein 1, GCAP 1, Guanylate cyclase activator 1A, GUCA1A, C6orf131, GCAP, GCAP1, GUCA1
Tested Applications
WB, IHC-P
Protein ID
46577585
Physical Properties
Liquid

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