STAT5b Antibody

• Background:

  STAT5b is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

• NCBI Gene ID:

  6777

• Swiss Prot:

  P51692

• Accession Number:

  P51692

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  This STAT5b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 760-787 amino acids from the C-terminal region of human STAT5b.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Pig

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  90 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  STAT5B

• NCBI Official Name:

  Signal transducer and activator of transcription 5B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Xi, S., et al., Cancer Res. 63 (20) :6763-6771 (2003) .

• Background Reference 02:

  Uddin, S., et al., Biochem. Biophys. Res. Commun. 308 (2) :325-330 (2003) .

• Background Reference 03:

  Zhang, X., et al., J. Allergy Clin. Immunol. 112 (1) :93-101 (2003) .

• Background Reference 04:

  Yamashita, H., et al., Oncogene 22 (11) :1638-1652 (2003) .

• Other Product Names:

  Signal transducer and activator of transcription 5B, STAT5B

• Tested Applications:

  WB, IHC-P

• Protein ID:

  41019536

• Physical Properties:

  Liquid