STAT5b Antibody

CAT: 0223-58-172Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-172Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
STAT5b is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
NCBI Gene ID
6777
Swiss Prot
P51692
Accession Number
P51692
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This STAT5b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 760-787 amino acids from the C-terminal region of human STAT5b.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
90 kDa
Fragment
Rabbit Ig
Symbol
STAT5B
NCBI Official Name
Signal transducer and activator of transcription 5B
NCBI Organism
Homo sapiens
Background Reference 01
Xi, S., et al., Cancer Res. 63 (20) :6763-6771 (2003) .
Background Reference 02
Uddin, S., et al., Biochem. Biophys. Res. Commun. 308 (2) :325-330 (2003) .
Background Reference 03
Zhang, X., et al., J. Allergy Clin. Immunol. 112 (1) :93-101 (2003) .
Background Reference 04
Yamashita, H., et al., Oncogene 22 (11) :1638-1652 (2003) .
Other Product Names
Signal transducer and activator of transcription 5B, STAT5B
Tested Applications
WB, IHC-P
Protein ID
41019536
Physical Properties
Liquid

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