PMS1 Antibody

• Background:

  This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.

• NCBI Gene ID:

  5378

• Swiss Prot:

  P54277

• Accession Number:

  P54277

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 694-722 amino acids from the C-terminal region of human PMS1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  106 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PMS1

• NCBI Official Name:

  PMS1 protein homolog 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hong, K.W., et al. J. Hum. Genet. 55 (6) :336-341 (2010)

• Background Reference 02:

  Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :

• Background Reference 03:

  Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

• Background Reference 04:

  Hosgood, H.D. III, et al. Respir Med 103 (12) :1866-1870 (2009)

• Other Product Names:

  PMS1 protein homolog 1, DNA mismatch repair protein PMS1, PMS1, PMSL1

• Tested Applications:

  WB

• Protein ID:

  1709683

• Physical Properties:

  Liquid